Effects of Moringa (Moringa oleifera) on the pharmacokinetics of nevirapine in HIV-infected adults: A clinical study
The present study was carried out to investigate the efficacy and safety of the Effects of Moringa (Moringa oleifera) on the iron status of Senegalese lactating women.
Moringa oleifera Lam., an herb commonly consumed by HIV-infected people on antiretroviral therapy, inhibits cytochrome P450 3A4, 1A2 and 2D6 activity in vitro; and may alter the pharmacokinetics (PK) of antiretroviral drugs metabolized via the same pathways. However, in vitro drug interaction activity may not translate to a clinically significant effect. Therefore, the effect of moringa leaf powder on the PK of nevirapine in HIV-infected people was investigated.
|Age (years), mean ± SD||44 ± 8|
|Sex, female, n (%)||8 (73)|
|Weight (kg), mean ± SD||63.5 ± 7.5|
|Drug frequency n (%)|
|Other drugs||3 (23)|
Co-administration of Moringa oleifera Lam. leaf powder at the traditional dose did not significantly alter the steady-state PK of nevirapine.
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