Effects of SYMPLOCOS RACEMOSA BARK (Lodhra bark) on HEPATOCELLULAR CAR

Effects of SYMPLOCOS RACEMOSA BARK (Lodhra bark) on HEPATOCELLULAR CARCINOMA: A clinical study

The present study was carried out to investigate the efficacy and safety of the Effects of SYMPLOCOS RACEMOSA BARK (Lodhra bark) on HEPATOCELLULAR CARCINOMA

Objective: To investigate in vitro anticancer activity of different extracts of bark of Symplocos racemosa against hepatocellular carcinoma.

Treatment Offered

Different successive extracts of Symplocos racemosa bark were prepared using hexane, chloroform, ethyl acetate, n-butanol, and water and were tested in vitro for cytotoxicity using (3-4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) assay in rat normal liver cells (BRL-3A) and human hepatocellular carcinoma (Hep3B) cells.

Results

Ethyl acetate and chloroform extract of Symplocos racemosa exhibited cytotoxicity against human hepatocellular carcinoma (Hep3B) cells in vitro with IC50 value (µg/ml) of 63.45 and 75.55 respectively and not affected the normal liver (BRL-3A) cells.

Conclusion

Symplocos racemosa bark extracts showed potential cytotoxic effects on human hepatocellular carcinoma cells. The anticancer activity exhibited by ethyl acetate and chloroform extract might be due to the presence of phenolics and flavonoid constituents present in the bark. Ethyl acetate extract can further be explored for possible cytotoxic activity using in vivo models of liver cancer.

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